Hyperestrinism in Dogs

Documentation from the University of  Tennesse

Hyperestrinism in dogs may be a new and emerging disease entity.  In sample submissions to the Clinical Endorinology Service (2005) at The University of Tennessee, 40% of adrenal panels had elevated estradiol levels present (>70 pg/ml).²⁹ In hyperestrinism cases, estradiol is the estrogen that is increased, ACTH stim and LDDS tests are usually normal for cortisol, thyroid function is normal or controlled, liver problems are frequent and typical (very elevated alkaline phosphatase, hepatomegaly, steroid hepatopathy, hyperechoic liver by ultrasound), PU/PD is frequent, panting may be present, haircoat problems often are present, skin biopsy results suggest an endocrinopathy, there is no change in estradiol level in response to ACTH stim or LDDS tests as currently conducted, resistance to mitotane may occur and increase often occurs in response to trilostane.  Effective treatment options for hyperestrinism in dogs is limited at the present time, and drugs that could be expected to be efficacious (aromatase inhibitors – excluding melatonin) often are limiting due to cost.  Melatonin and phytoestrogen treatment may be effective for the above listed reasons.  Mitotane will likely be effective if the source of estradiol is the adrenal tissues.  Trilostane treatment frequently results in increased estradiol levels,²⁹ and this may be a reason why less than effective treatment with the drug sometimes occurs.

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Tagged as: cortisol, disease, dogs, estrogen, liver